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BPC‑157 (Body Protection Compound‑157) is a research-grade, synthetic 15‑amino‑acid peptide originally identified in human gastric juice and later synthesized for laboratory studies. Unlike many endocrine-related peptides, it’s primarily examined for its potential in tissue repair, inflammation modulation, and protective mechanisms across multiple organ systems.
Description
BPC‑157 (also known as PL 14736, Body Protection Compound‑157, or bepecin) is a synthetic, research‑grade pentadecapeptide originally derived from studies of human gastric juice. Its 15‑amino‑acid sequence is Gly‑Glu‑Pro‑Pro‑Pro‑Gly‑Lys‑Pro‑Ala‑Asp‑Asp‑Ala‑Gly‑Leu‑Val. Preclinical models suggest cytoprotective and pro‑healing activity across gastrointestinal and musculoskeletal tissues.
Chemical Structure / Identifiers
| Property | Detail |
| Sequence | Gly‑Glu‑Pro‑Pro‑Pro‑Gly‑Lys‑Pro‑Ala‑Asp‑Asp‑Ala‑Gly‑Leu‑Val (PMC, PubChem) |
| Molecular Formula | C62H98N16O22 (PubChem) |
| Molecular Weight | ≈ 1419.55 g/mol (MDPI Pharmaceuticals 2025) |
| Synonyms | PL 14736; Body Protection Compound‑157; Bepecin (Wikipedia/PMID reviews) |
| CAS Number | 137525‑51‑0 (Wikipedia) |
| PubChem CID | 9941957 (PubChem) |
Primary Research Focus
• Gastrointestinal mucosal protection and ulcer healing in rodent models. (PMC)
• Tendon, ligament, and muscle healing: accelerated recovery in transected tendon and surgically injured ligament models; enhanced tendon‑cell outgrowth and survival in vitro. (PubMed)
• Skin wound healing in hyperglycemic rats. (PubMed)
• Broad cytoprotective and angiogenic effects discussed in narrative reviews; emerging interest in orthopaedic sports medicine. (PMC)
Safety / Limitations
• Not FDA‑approved; human clinical data remain limited. (Wikipedia; narrative reviews)
• Some clinical experience reported in inflammatory bowel disease trials, but robust, peer‑reviewed randomized human studies are sparse. (PubMed/PMC)
• Unregulated supply chains and variability in product quality are frequent concerns. (PMC review, 2025)
• Research Use Only; safety and efficacy have not been established for diagnosis, treatment, or prevention of disease.
Key Publications / References
Pentadecapeptide BPC 157 enhances the growth of tendon out from tendon explants and fibroblast migration (Journal of Applied Physiology). PubMed: https://pubmed.ncbi.nlm.nih.gov/21030672/ PMC overview: https://pmc.ncbi.nlm.nih.gov/articles/PMC6271067/
Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tenocyte growth. J Orthop Res. 2003;21(6):976‑983. PubMed: https://pubmed.ncbi.nlm.nih.gov/14554208/
PL‑14736 (BPC‑157) accelerates deficient skin wound healing in hyperglycemic rats. J Vasc Res. 2006;43(5):386‑394. PubMed: https://pubmed.ncbi.nlm.nih.gov/16785777/
Stable gastric pentadecapeptide BPC 157: review of anti‑ulcer and systemic cytoprotective effects. World J Gastroenterol. 2015. PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC4717094/
Stable gastric pentadecapeptide BPC 157 as a therapy in rats with quadriceps tendon dissection. Int J Mol Sci. 2021. PubMed: https://pubmed.ncbi.nlm.nih.gov/34829776/
Emerging use of BPC‑157 in orthopaedic sports medicine (2025 review). PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC12313605/
PubChem Compound Summary for BPC‑157. PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Bpc-157
Pharmaceuticals 2025 review: Multifunctionality and possible medical application of BPC‑157. MDPI: https://www.mdpi.com/1424-8247/18/2/185
Wikipedia entry for cross‑checking identifiers (CAS, synonyms). https://en.wikipedia.org/wiki/BPC-157
Reviews
There are no reviews yet.