Description

Eterna Peptides presents premium-grade MOTS-c lyophilized powder, an elite mitochondrial-derived peptide (MDP) comprised of a unique 16-amino-acid sequence (Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Ala-Pro-Arg-Pro-Pro-Ala). Encoded within the short open reading frame of the mitochondrial 12S rRNA gene, MOTS-c acts as an autonomous non-nuclear signaling molecule. Available in 5mg, 10mg, and 20mg vial configurations, this metabolic master regulator serves as a premier investigative tool for tracking systemic metabolic homeostasis, cellular longevity, and mitochondrial-nuclear communication pathways.

### Available Research Configurations
* **MOTS-c 5mg Vial:** Standardized for targeted cellular assays, exploratory baseline studies, and tight-tolerance metabolic screens.
* **MOTS-c 10mg Vial:** Calibrated for mid-tier longitudinal protocols, mitochondrial signaling assays, and multi-subject tissue culture modeling.
* **MOTS-c 20mg Vial:** Ultra-concentrated presentation engineered for continuous high-saturation exposure trials and intensive metabolic stress screens.

### Mechanism of Action
MOTS-c operates as an endocrine-like signaling factor that directly interfaces with both cytoplasmic and nuclear pathways:
* **AMPK Activation & AICAR Mimicry:** MOTS-c functions as an elegant metabolic catalyst by activating the AMP-activated protein kinase ($AMPK$) pathway. It blocks the folate-dependent de novo purine synthesis pathway, leading to an accumulation of AICAR, which stimulates glucose uptake and lipid beta-oxidation ($ \beta\text{-oxidation} $).
* **Mitochondrial-Nuclear Translocation:** Under metabolic stress or physical exertion modeling, MOTS-c translocates directly to the cell nucleus. Once inside, it binds to specific promoter regions to regulate the adaptive transcription of nuclear genes, protecting cells against oxidative stress.
* **Insulin Sensitivity Stabilization:** Research demonstrates that MOTS-c directly enhances glucose clearance mechanics by upregulating glucose transporter-4 ($GLUT4$) expression in skeletal muscle tissue, reversing baseline insulin resistance models.
* **Osteoblast Differentiation & Tissue Density:** In structural degradation models, MOTS-c signaling tracks the up-regulation of Type I collagen synthesis and promotes osteoblast differentiation via TGF-beta/Smad pathways, exploring the mitigation of bone mineral density loss.

### Research Applications
In preclinical and in vitro laboratory models, MOTS-c vials are actively utilized to investigate:
* Systemic metabolic rate acceleration, adipose tissue repartitioning, and obesity resistance kinetics.
* Enhanced exercise capacity modeling, cellular oxygenation efficiency, and skeletal muscle ATP synthesis.
* Mitochondrial-directed chronological longevity, cellular senescence mitigation, and transcriptomic stress adaptation.
* Advanced musculoskeletal profiling, osteoblast proliferation, and bone mineral retention pathways.

Our MOTS-c vials undergo strict laboratory stabilization, purification, and vacuum-drying guidelines to ensure absolute peptide chain integrity, rapid reconstitution kinetics, and dependable experimental reproducibility.

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*Disclaimer: This product is sold strictly for laboratory research and development use only. It is not intended for human consumption, diagnostic, or therapeutic purposes.*