Description

Eterna Peptides presents premium-grade VIP (10mg) lyophilized powder, a highly purified synthetic formulation of Vasoactive Intestinal Peptide. Composed of a 28-amino-acid sequence, VIP acts as a potent endogenous signaling hormone and neuromodulator within the glucagon/secretin superfamily. Extensively investigated across pulmonology, immunology, and vascular biology, this precise 10mg formulation serves as a premier investigative tool for tracking smooth muscle relaxation kinetics, systemic immunomodulation, and alveolar-capillary barrier homeostatic modeling.

### Mechanism of Action
VIP operates as a multi-pathway biological master regulator, driving targeted cellular cascades:
* **Vasodilation & Smooth Muscle Relaxation:** VIP binds with high affinity to specific G-protein coupled receptors, primarily VPAC1 and VPAC2. This binding triggers an intracellular adenylate cyclase cascade, elevating cyclic adenosine monophosphate ($cAMP$) levels. The rise in cAMP drives downstream protein kinase A (PKA) activation, prompting profound smooth muscle relaxation and microvascular blood flow optimization.
* **Immune Cascade & Cytokine Modulation:** In inflammatory modeling, VIP functions as a potent immunomodulatory agent. It actively suppresses the transcription of pro-inflammatory cytokines—including TNF-alpha, IL-1 beta, and IL-6—while upregulating anti-inflammatory mediators like IL-10, helping stabilize cellular boundaries under severe oxidative stress.
* **Pulmonary Architecture Protection:** Research demonstrates that VIP signaling plays a critical role in evaluating pulmonary arterial pressure homeostasis. It is tracked in preclinical models for its ability to mitigate cellular hypertrophy and slow down the structural remodeling of delicate alveolar vascular walls.
* **Neuroprotective & Barrier Stabilization:** Beyond vascular beds, VIP interfaces with central and peripheral neural structures to preserve blood-brain barrier integrity, balance microglial activation curves, and support local tissue longevity parameters.

### Research Applications
In preclinical and in vitro laboratory models, VIP 10mg vials are actively utilized to investigate:
* Advanced microvascular perfusion, peripheral vasodilation mechanics, and endothelial health indexing.
* Pulmonary tissue remodeling, alveolar structural preservation, and respiratory vascular resistance mapping.
* Systemic and localized anti-inflammatory signaling pathways, mast cell stabilization, and macrophage phenotype shifts.
* The comparative baseline binding affinity and stability curves of VPAC1 and VPAC2 receptor agonists.

Our VIP vials undergo strict laboratory quality control, stabilization, and vacuum-drying guidelines to ensure absolute structural purity, rapid dissolution kinetics, and dependable experimental reproducibility.

—
*Disclaimer: This product is sold strictly for laboratory research and development use only. It is not intended for human consumption, diagnostic, or therapeutic purposes.*