$75.00
10mg – Lyophilized *MUST BE RECONSTITUTED FOR RESEARCH APPLICATIONS*
Selank 10mg is an advanced, high-purity synthetic 7-amino-acid Tuftsin analogue engineered to study targeted central anxiolytic pathways, enkephalin preservation, and neurocognitive longevity. By pairing its structural core with a stabilizing Pro-Gly-Pro sequence to resist proteolytic cleavage, this premium peptide serves as an elite investigative tool for tracking sustained BDNF expression, non-sedating GABAergic modulation, and prefrontal neurotransmitter stabilization in laboratory models under acute stress simulation.
Supplied as a stable, premium-grade lyophilized powder in a single 10mg vial. Restricted strictly to laboratory and in vitro evaluation.
Eterna Peptides presents premium-grade Selank (10mg) lyophilized powder, an elite synthetic analogue of the endogenous immunomodulatory peptide Tuftsin. Structurally optimized as a heptapeptide sequence (Thr-Lys-Pro-Arg-Pro-Gly-Pro), Selank incorporates a stabilizing Pro-Gly-Pro tripeptide sequence at its C-terminus to drastically enhance its resistance to proteolytic degradation and extend its experimental half-life within the central nervous system. Extensively evaluated within neurobiology, psychopharmacology, and behavioral sciences, this precise 10mg single-vial format serves as a premier investigative tool for tracking targeted anxiolytic pathways, neuropsychiatric stabilization, and cognitive longevity metrics without triggering sedating or habit-forming cascades.
### Mechanism of Action
Selank operates via a multifaceted neurochemical network to modulate stress, anxiety, and cognitive architecture:
* **Enkephalin Degradation Blockade:** Selank functions as a potent inhibitor of enkephalin-degrading enzymes, specifically targeting carboxypeptidase N and neutral endopeptidase. By halting this breakdown, it sustains elevated concentrations of endogenous enkephalins inside the brain, reinforcing natural opioid-mediated anxiolytic and stress-mitigating signaling pathways.
* **GABAergic Neurotransmitter Tuning:** In neuronal culture models, Selank modulates $GABA_A$ receptor complex dynamics, enhancing inhibitory neurotransmission. Crucially, it achieves this allosteric tuning without inducing the typical motor-impairing, hypnotic, or sedative side profiles associated with traditional benzodiazepine receptor agonists.
* **BDNF Axis & Synaptic Plasticity Support:** Preclinical data shows Selank upregulates the transcription and expression of Brain-Derived Neurotrophic Factor ($BDNF$) within the hippocampus. This cascade is tracked for its direct role in promoting spinogenesis, long-term potentiation ($LTP$), and synaptic plasticity under simulated cognitive fatigue.
* **Serotonergic & Dopaminergic Homeostasis:** Selank alters monoamine turnover rates in the prefrontal cortex and hippocampus, stabilizing serotonin and dopamine signaling pathways during periods of high acute environmental stress or chemical disruption.
### Research Applications
In preclinical and in vitro laboratory models, Selank 10mg vials are actively utilized to investigate:
* High-velocity anxiety-extinction signaling, fear-conditioned response moderation, and emotional stress resilience.
* Hippocampal BDNF upregulation, neurite outgrowth kinetics, and neuro-protective memory preservation pathways.
* Epigenetic and transcriptomic changes involving enkephalin-conserving enzyme inhibition kinetics.
* Neuropeptide-driven immunomodulation, cytokine balancing, and blood-brain barrier transport dynamics.
Our Selank vials undergo strict laboratory stabilization, high-grade purification, and uniform vacuum-drying guidelines to ensure absolute peptide chain integrity, rapid reconstitution kinetics, and dependable experimental reproducibility.
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*Disclaimer: This product is sold strictly for laboratory research and development use only. It is not intended for human consumption, diagnostic, or therapeutic purposes.*
