$50.00
10mg – Lyophilized *MUST BE RECONSTITUTED FOR RESEARCH APPLICATIONS*
PT-141 10mg (Bremelanotide) is an advanced, high-purity synthetic cyclic heptapeptide and alpha-MSH analogue engineered to study central nervous system mediated libido amplification, hypothalamic receptor signaling, and microvascular blood flow dynamics. By selectively targeting central MC3R and MC4R pathways to drive localized dopaminergic surges and upregulate nitric oxide synthase without relying on peripheral vascular pathways, this precisely calibrated 10mg presentation stands as a premier investigative tool for tracking advanced neuro-arousal behavior, pelvic tissue perfusion, and autonomic signaling curves in laboratory models for up to 24 hours.
Supplied as a stable, premium-grade lyophilized powder in a single 10mg vial. Restricted strictly to laboratory and in vitro evaluation.
Eterna Peptides presents premium-grade PT-141 (10mg) lyophilized powder, an elite synthetic peptide analogue of alpha-melanocyte-stimulating hormone ($\alpha\text{-MSH}$). Structurally classified as Bremelanotide, PT-141 is a cyclic heptapeptide sequence (Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH) that lacks the non-selective cardiovascular constraints of its predecessor, Melanotan II. Extensively evaluated within neurobiology, endocrinology, and reproductive sciences, this precise 10mg single-vial format serves as a premier investigative tool for tracking central nervous system mediated arousal, melanocortin receptor mapping, and microvascular nitric oxide dynamics.
### Mechanism of Action
PT-141 operates via a highly specialized central neurochemical pathway rather than targeting the peripheral vascular system directly:
* **Melanocortin Receptor Co-Agonism:** PT-141 functions as a high-affinity agonist primarily targeting the central Melanocortin Receptors MC3R and MC4R inside the central nervous system. This activation skips peripheral tissues and interfaces directly with neural circuitry.
* **Hypothalamic Signaling & Dopaminergic Activation:** Upon binding to MC4R networks within the medial preoptic area ($mPOA$) and the paraventricular nucleus ($PVN$) of the hypothalamus, PT-141 triggers a downstream surge in localized dopaminergic signaling. This central pathway is the primary model investigated for its ability to elevate intrinsic sexual desire, libido metrics, and behavioral motivation cascades.
* **Nitric Oxide Axis & Autonomic Outflow:** Enhanced hypothalamic activation modulates spinal cord autonomic efferent paths, prompting an upregulation of neuronal and endothelial Nitric Oxide Synthase ($NOS$). The subsequent elevation of local nitric oxide ($NO$) drives smooth muscle relaxation, serving as a premier model for tracking improved physiological erection potential and microvascular blood flow velocity.
* **Avoidance of Peripheral Vasoconstriction:** By omitting the skin-pigmenting mechanisms of MC1R saturation and the non-selective pressor issues of older molecules, PT-141 allows for the precise isolation of behavioral neuro-arousal parameters during control screens.
### Research Applications
In preclinical and in vitro laboratory models, PT-141 10mg vials are actively utilized to investigate:
* Central nervous system regulated libido amplification, hypothalamic dopamine surges, and behavioral motivation curves.
* Melanocortin receptor saturation dynamics, receptor sub-type binding affinity curves, and secondary messenger cAMP kinetics.
* Intracellular nitric oxide expression pathways, pelvic microvascular perfusion velocities, and autonomic reflex alignment.
* Comparative signaling durations, tracking human model clinical data indicating elevated arousal curves extending up to 24 hours post-exposure.
Our PT-141 vials undergo strict laboratory stabilization, high-grade purification, and uniform vacuum-drying guidelines to ensure absolute peptide chain integrity, rapid reconstitution kinetics, and dependable experimental reproducibility.
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*Disclaimer: This product is sold strictly for laboratory research and development use only. It is not intended for human consumption, diagnostic, or therapeutic purposes.*
